mr. drs. I.J. (Pieter) Michels

mr. drs. I.J. (Pieter) Michels

Associate Professor
mr. drs. I.J. (Pieter) Michels
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health



Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), and NWO Vidi Grant (2020). In 2021, Pieter was award the Prix Galien Research Award for his work on drug delivery.

Fellowship and Awards

  • 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
  • 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles" 
  • 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
  • 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms” 
  • 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"

Research Output (68)

Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function

van de Wakker S. I., van Oudheusden J., Mol E. A., Roefs M. T., Zheng W., Görgens A., El Andaloussi S., Sluijter J. P.G., Vader P. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 59-69 11 p.

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Raes Laurens, Pille Melissa, Harizaj Aranit, Goetgeluk Glenn, Van Hoeck Jelter, Stremersch Stephan, Fraire Juan C., Brans Toon, de Jong Olivier Gerrit, Maas-Bakker Roel, Mastrobattista Enrico, Vader Pieter, De Smedt Stefaan C., Vandekerckhove Bart, Raemdonck Koen, Braeckmans Kevin 3 Sep 2021, In: Molecular Therapy - Nucleic Acids. 25 , p. 696-707 12 p.

Illuminating RNA trafficking and functional delivery by extracellular vesicles

de Voogt Willemijn S., Tanenbaum Marvin E., Vader Pieter Jul 2021, In: Advanced Drug Delivery Reviews. 174 , p. 250-264 15 p.

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Sork Helena, Conceicao Mariana, Corso Giulia, Nordin Joel, Lee Yi Xin Fiona, Krjutskov Kaarel, Orzechowski Westholm Jakub, Vader Pieter, Pauwels Marie, Vandenbroucke Roosmarijn E., Wood Matthew Ja, El Andaloussi Samir, Mäger Imre 18 Jun 2021, In: Cells. 10 , p. 1-17

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Rankin-Turner Stephanie, Vader Pieter, O'Driscoll Lorraine, Giebel Bernd, Heaney Liam M., Davies Owen G. Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 479-491 13 p.

Approaches to surface engineering of extracellular vesicles

Richter Maximilian, Vader Pieter, Fuhrmann Gregor Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 416-426 11 p.

Natural or Synthetic RNA Delivery:A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Murphy Daniel E, de Jong Olivier G, Evers Martijn J W, Nurazizah Maratussholikhah, Schiffelers Raymond M, Vader Pieter 11 Feb 2021, In: Nano letters. 21 , p. 1888-1895 8 p.

Hydrogel-Induced Cell Membrane Disruptions Enable Direct Cytosolic Delivery of Membrane-Impermeable Cargo

Van Hoeck Jelter, Van de Vyver Thijs, Harizaj Aranit, Goetgeluk Glenn, Merckx Pieterjan, Liu Jing, Wels Mike, Sauvage Félix, De Keersmaecker Herlinde, Vanhove Christian, de Jong Olivier G., Vader Pieter, Dewitte Heleen, Vandekerckhove Bart, Braeckmans Kevin, De Smedt Stefaan C., Raemdonck Koen 2021, In: Advanced materials. 33 , p. 1-19

Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles

Evers Martijn J.W., van de Wakker Simonides I., de Groot Ellis M., de Jong Olivier G., Gitz-François Jerney J.J., Seinen Cor S., Sluijter Joost P.G., Schiffelers Raymond M., Vader Pieter 2021, In: Advanced Healthcare Materials. 11 , p. 1-13

Extracellular Vesicle-Associated Proteins in Tissue Repair

Roefs Marieke T, Sluijter Joost P G, Vader Pieter Dec 2020, In: Trends in Cell Biology. 30 , p. 990-1013 24 p.

All research output

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