mr. drs. I.J. (Pieter) Michels
mr. drs. I.J. (Pieter) Michels
- Central Diagnostic Laboratory
Research Programs
Biography
Biography
Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.
From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.
In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), and NWO Vidi Grant (2020). In 2021, Pieter was award the Prix Galien Research Award for his work on drug delivery.
Fellowship and Awards
- 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
- 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles"
- 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
- 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms”
- 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"
Research Output (68)
van de Wakker S. I., van Oudheusden J., Mol E. A., Roefs M. T., Zheng W., Görgens A., El Andaloussi S., Sluijter J. P.G., Vader P. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 59-69 11 p.
Raes Laurens, Pille Melissa, Harizaj Aranit, Goetgeluk Glenn, Van Hoeck Jelter, Stremersch Stephan, Fraire Juan C., Brans Toon, de Jong Olivier Gerrit, Maas-Bakker Roel, Mastrobattista Enrico, Vader Pieter, De Smedt Stefaan C., Vandekerckhove Bart, Raemdonck Koen, Braeckmans Kevin 3 Sep 2021, In: Molecular Therapy - Nucleic Acids. 25 , p. 696-707 12 p.
de Voogt Willemijn S., Tanenbaum Marvin E., Vader Pieter Jul 2021, In: Advanced Drug Delivery Reviews. 174 , p. 250-264 15 p.
Sork Helena, Conceicao Mariana, Corso Giulia, Nordin Joel, Lee Yi Xin Fiona, Krjutskov Kaarel, Orzechowski Westholm Jakub, Vader Pieter, Pauwels Marie, Vandenbroucke Roosmarijn E., Wood Matthew Ja, El Andaloussi Samir, Mäger Imre 18 Jun 2021, In: Cells. 10 , p. 1-17
Rankin-Turner Stephanie, Vader Pieter, O'Driscoll Lorraine, Giebel Bernd, Heaney Liam M., Davies Owen G. Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 479-491 13 p.
Richter Maximilian, Vader Pieter, Fuhrmann Gregor Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 416-426 11 p.
Murphy Daniel E, de Jong Olivier G, Evers Martijn J W, Nurazizah Maratussholikhah, Schiffelers Raymond M, Vader Pieter 11 Feb 2021, In: Nano letters. 21 , p. 1888-1895 8 p.
Van Hoeck Jelter, Van de Vyver Thijs, Harizaj Aranit, Goetgeluk Glenn, Merckx Pieterjan, Liu Jing, Wels Mike, Sauvage Félix, De Keersmaecker Herlinde, Vanhove Christian, de Jong Olivier G., Vader Pieter, Dewitte Heleen, Vandekerckhove Bart, Braeckmans Kevin, De Smedt Stefaan C., Raemdonck Koen 2021, In: Advanced materials. 33 , p. 1-19
Evers Martijn J.W., van de Wakker Simonides I., de Groot Ellis M., de Jong Olivier G., Gitz-François Jerney J.J., Seinen Cor S., Sluijter Joost P.G., Schiffelers Raymond M., Vader Pieter 2021, In: Advanced Healthcare Materials. 11 , p. 1-13
Roefs Marieke T, Sluijter Joost P G, Vader Pieter Dec 2020, In: Trends in Cell Biology. 30 , p. 990-1013 24 p.