mr. drs. J.K.K. (Evelyn) Meuwissen

mr. drs. J.K.K. (Evelyn) Meuwissen

Assistant Professor
mr. drs. J.K.K. (Evelyn) Meuwissen
  • Epi Kanker Team C
  • Julius Center Research Program Cancer

Research Programs

Strategic Program Cancer



Evelyn Monninkhof studied Biomedical Health Sciences at the Catholic University Nijmegen. In 1998, she obtained her Master’s degree in Epidemiology. In 1999, she started a PhD project at Medisch Spectrum Twente hospital in Enschede and the Department of Epidemiology at the University Medical Center Nijmegen. In February 2004, she completed her thesis on ‘Medical and behavioural interventions in COPD: the COPE study’. Since October 2003, she is working at the Julius Center for Health Sciences and Primary care as a postdoc researcher in the field of cancer epidemiology, obesity and physical activity. Furthermore, she is a teacher in Epidemiology & Evidence Based Medicine and methodological consultant for the department of Radiotherapy.

Interests and Focus

Main research interest of Evelyn Monninkhof is directed towards physical activity, obesity and (breast) cancer risk. She has been coordinating/ involved in several randomised controlled trials studying the effect of exercise on breast cancer risk or outcome after breast cancer diagnosis:

  • The SHAPE-1 study examined the effects of a 1-year exercise programme on endogenous hormone levels (associated with breast cancer among 189 sedentary postmenopausal women.
  • The SHAPE-2 study examined the effect of weight loss mainly driven by exercise compared to equivalent weight loss due to a calorie restricted diet only on sex hormone levels. In addition, the role of total body fat and intra-abdominal fat was explored.
  • The UMBRELLA- Fit trial: a trial investigating the effects of physical activity in breast cancer patients applying a new study design (the cmRCT design)
  • The PAM (Physical Activity & Exercise) study. This study investigates the effects of exercise on cognitive function in breast cancer patients with complaints in this area after chemotherapy treatment.

Besides above mentioned trials, Evelyn is also involved in the DENSE trial: a very large trial studying the cost-effectiveness of biennial screening with MRI + mammography compared to mammography alone in women aged 50-75 years with extremely dense breasts. At the radiotherapy department, she is involved in the FLAME trial. This trial invetsigates standard fractionated external beam radiotherapy (EBRT) with and without an additional integrated boost to the macroscopically visible tumour in patients with localized prostate cancer on disease-free survival and side effects.

Side Activities

-         Member (methodologist) of the Medical Ethical Committee of the UMC Utrecht

-         Member of the tracer pool of the UMC Utrecht

-         Consultant at the Julius Support office

Fellowship and Awards


Research Output (141)

"Who needs a mean dose if you can FLAME?"

Guricová Karolína, van der Heide Uulke A, Kerkmeijer Linda G W, Pos Floris, Monninkhof Evelyn, Haustermans Karin Sep 2022, In: Radiotherapy & Oncology. 174 , p. 171-172 2 p.

Patterns of Failure Following External Beam Radiotherapy With or Without an Additional Focal Boost in the Randomized Controlled FLAME Trial for Localized Prostate Cancer

Groen Veerle H., Haustermans Karin, Pos Floris J., Draulans Cédric, Isebaert Sofie, Monninkhof Evelyn M., Smeenk Robert J., Kunze-Busch Martina, de Boer Johannes C.J., van der Voort van Zijp Jochem, Kerkmeijer Linda G.W., van der Heide Uulke A. Sep 2022, In: European Urology. 82 , p. 252-257 6 p.

Quality of Life After Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Patients With Bone Metastases

Pielkenrood Bart J, Gal Roxanne, Kasperts Nicolien, Verhoeff Joost Jc, Bartels Marcia Mtj, Seravalli Enrica, van der Linden Yvette M, Monninkhof Evelyn M, Verlaan Jorrit-Jan, van der Velden Joanne M, Verkooijen Helena M 10 Jan 2022, In: International Journal of Radiation Oncology Biology Physics. 112 , p. 1203-1215 13 p.

Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Groen Veerle H, van Schie Marcel, Zuithoff Nicolaas P A, Monninkhof Evelyn M, Kunze-Busch Martina, de Boer Johannes C J, van der Voort van Zijp Jochem, Pos Floris J, Smeenk Robert Jan, Haustermans Karin, Isebaert Sofie, Draulans Cédric, Depuydt Tom, Verkooijen Helena M, van der Heide Uulke A, Kerkmeijer Linda G W 28 Dec 2021, In: Radiotherapy & Oncology. 167 , p. 127-132 6 p.

Cost-Effectiveness of Magnetic Resonance Imaging Screening for Women With Extremely Dense Breast Tissue

Geuzinge H Amarens, Bakker Marije F, Heijnsdijk Eveline A M, van Ravesteyn Nicolien T, Veldhuis Wouter B, Pijnappel Ruud M, de Lange Stéphanie V, Emaus Marleen J, Mann Ritse M, Monninkhof Evelyn M, de Koekkoek-Doll Petra K, van Gils Carla H, de Koning Harry J, 2 Nov 2021, In: Journal of the National Cancer Institute. 113 , p. 1476-1483 8 p.

Reducing false-positive screening MRI rate in women with extremely dense breasts using prediction models based on data from the DENSE trial

den Dekker Bianca M., Bakker Marije F., de Lange Stéphanie V., Veldhuis Wouter B., van Diest Paul J., Duvivier Katya M., Lobbes Marc B.I., Loo Claudette E., Mann Ritse M., Monninkhof Evelyn M., Veltman Jeroen, Pijnappel Ruud M., van Gils Carla H. Nov 2021, In: Radiology. 301 , p. 283-292 10 p.

Effects of exercise in breast cancer patients:implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

Gal Roxanne, Monninkhof Evelyn M, van Gils Carla H, Groenwold Rolf H H, Elias Sjoerd G, van den Bongard Desirée H J G, Peeters Petra H M, Verkooijen Helena M, May Anne M 24 Aug 2021, In: Breast Cancer Research and Treatment. 190 , p. 89-101 13 p.

Urethra and bladder dose-effect relations for genitourinary toxicity after EBRT for prostate cancer

Groen V., van Schie M., Zuithoff N. P., Monninkhof E. M., Kunze-Busch M., de Boer J. C., van Zijp J. van der Voort, Pos F. J., Smeenk R. J., Haustermans K., Isebaert S., Draulans C., Verkooijen H. M., van der Heide U. A., Kerkmeijer L. G. Aug 2021, In: Radiotherapy and Oncology. 161 , p. S393-S395

Quality of Life after Palliative Radiotherapy for Bone Metastases: Analysis of the PRESENT-cohort

Bartels M., van der Velden J., Pielkenrood B., Gerlich S., Bras M., Verlaan J., Monninkhof E., Peters M., van der Linden Y., Verkooijen H. Aug 2021, In: Radiotherapy and Oncology. 161 , p. S302-S303

Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Groen Veerle H., Zuithoff Nicolaas P.A., van Schie Marcel, Monninkhof Evelyn M., Kunze-Busch Martina, de Boer Hans C.J., van der Voort van Zyp Jochem, Pos Floris J., Smeenk Robert Jan, Haustermans Karin, Isebaert Sofie, Draulans Cédric, Depuydt Tom, Verkooijen Helena M., van der Heide Uulke A., Kerkmeijer Linda G.W. 29 Jun 2021, In: Radiotherapy and Oncology. 162 , p. 98-104 7 p.

All research output

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