prof. dr. I. (Jaco J.M.) Luttikhuizen

prof. dr. I. (Jaco J.M.) Luttikhuizen

Associate Professor
prof. dr. I. (Jaco J.M.) Luttikhuizen



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant "Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)" (2013, ERC grant agreement n°337333).

Vici grant: "Seismology of the brain - A new approach for probing the brain’s microvasculature and tissue properties" (2021)

Research Output (138)

Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI

Verbeek-Spijkerman Jolanda, Zwanenburg J. J.M., Bouvy W. H., Geerlings M. I., Biessels G. J., Hendrikse J., Luijten P. R., Kuijf H. J. 13 Apr 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-9

Pulsatility Index in the Basal Ganglia Arteries Increases with Age in Elderly with and without Cerebral Small Vessel Disease

Perosa V, Arts T, Assmann A, Mattern H, Speck O, Oltmer J, Heinze H-J, Düzel E, Schreiber S, Zwanenburg J J M 24 Mar 2022, In: AJNR. American journal of neuroradiology. 43 , p. 540-546 7 p.

Dynamic brain ADC variations over the cardiac cycle and their relation to tissue strain assessed with DENSE at high-field MRI

Sloots Jacob-Jan, Froeling Martijn, Biessels Geert Jan, Zwanenburg Jaco J M 2022, In: Magnetic Resonance in Medicine. 88 , p. 266-279 14 p.

Does the Internal Carotid Artery Attenuate Blood-Flow Pulsatility in Small Vessel Disease?:A 7 T 4D-Flow MRI Study

van Tuijl Rick J, Ruigrok Ynte M, Geurts Lennart J, van der Schaaf Irene C, Biessels Geert Jan, Rinkel Gabriël J E, Velthuis Birgitta K, Zwanenburg Jaco J M 2022, In: Journal of Magnetic Resonance Imaging.

Detecting low blood concentrations in joints using T1 and T2 mapping at 1.5, 3, and 7 T:an in vitro study

van Leeuwen Flora H P, Lena Beatrice, Zwanenburg Jaco J M, van Vulpen Lize F D, Bartels Lambertus W, Fischer Kathelijn, Nap Frank J, de Jong Pim A, Bos Clemens, Foppen Wouter 2 Dec 2021, In: European radiology experimental. 5

An anomaly detection approach to identify chronic brain infarcts on MRI

van Hespen Kees M, Zwanenburg Jaco J M, Dankbaar Jan W, Geerlings Mirjam I, Hendrikse Jeroen, Kuijf Hugo J Dec 2021, In: Scientific Reports. 11

Pulsatility attenuation along the carotid siphon in pseudoxanthoma elasticum

Bartstra J. W., van Tuijl R. J., de Jong P. A., Mali W. P.T.M., van der Schaaf I. C., Ruigrok Y. M., Rinkel G. J.E., Velthuis B. K., Spiering W., Zwanenburg J. J.M. 1 Nov 2021, In: American Journal of Neuroradiology. 42 , p. 2030-2033 4 p.

Double delay alternating with nutation for tailored excitation facilitates banding-free isotropic high-resolution intracranial vessel wall imaging

Coolen Bram F, Schoormans Jasper, Gilbert Guillaume, Kooreman Ernst S, de Winter Naomi, Viessmann Olivia, Zwanenburg Jaco J M, Majoie Charles B.L.M., Strijkers Gustav J, Nederveen Aart J, Siero Jeroen C W 2 Jun 2021, In: NMR in Biomedicine. 34 10 p.

Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI

Arts Tine, Meijs Timion A, Grotenhuis Heynric, Voskuil Michiel, Siero Jeroen, Biessels Geert Jan, Zwanenburg Jaco 26 Apr 2021, In: Frontiers in Neuroscience. 15 10 p.

Strain Tensor Imaging:Cardiac-induced brain tissue deformation in humans quantified with high-field MRI

Sloots Jacob-Jan, Biessels Geert Jan, de Luca Alberto, Zwanenburg Jaco J M 18 Apr 2021, In: NeuroImage. 236 , p. 1-14

All research output

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