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ir. drs. A. (Alwin) Link

ir. drs. A. (Alwin) Link

Full Professor
ir. drs. A. (Alwin) Link
  • Clinical Pharmacy

Research Programs

Strategic Program Cancer

Side Activities

2002 - 2021 : Member of the Medical Ethical Committee of Netherlands Cancer Institute

2003 - : Involved in many early clinical trials of novel anticancer agents (not further specified, revenues for Netherlands Cancer Institute, Princess Máxima Center of University Medical Center Utrecht)

2016 - 2018: Member of scientific councel "Stichting Kinderen Kankervrij (KiKa)"

2017 - 2021 : Member of the working group Oncology & Hematology of "Horizonscan geneesmiddelen", ZorgInstituut Nederland

2018 - : Board member of Dutch Society of Clinical Pharmacology & Biopharmaceutics

2021 - 2022: Member of the external evaluation committee of 10 year program "Goed Geneesmiddelen Gebruik"

Fellowship and Awards

2015 Galenus research prize

2014 Huizinga penning of the Dutch Association of Hospital Pharmacists

Research Output (242)

Exposure–Response Analysis of Osimertinib in EGFR Mutation Positive Non-Small Cell Lung Cancer Patients in a Real-Life Setting

Boosman René J., Jebbink Merel, Veldhuis Wouter B., Groenland Stefanie L., van Veggel Bianca A.M.H., Moeskops Pim, de Langen Adrianus J., Beijnen Jos H., Smit Egbert F., Huitema Alwin D.R., Steeghs Neeltje Oct 2022, In: Pharmaceutical Research. 39 , p. 2507-2514 8 p.

A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS

van der Heijden L T, Gebretensae A, Thijssen B, van Andel L, Nijstad A L, Wang Y, Rosing H, Huitema A D R, Beijnen J H 5 Jun 2022, In: Journal of Pharmaceutical and Biomedical Analysis. 215 , p. 1-8

Is age just a number?:A population pharmacokinetic study of gemcitabine

Boosman René J, Crombag Marie-Rose B S, van Erp Nielka P, Beijnen Jos H, Steeghs Neeltje, Huitema Alwin D R May 2022, In: Cancer Chemotherapy and Pharmacology. 89 , p. 697-705 9 p.

Optimized sample pre-treatment procedure for the simultaneous UPLC-MS/MS quantification of ipilimumab, nivolumab, and pembrolizumab in human serum

de Jong Karen A M, Rosing Hilde, Huitema Alwin D R, Beijnen Jos H 30 Apr 2022, In: Journal of Chromatography B. 1196 , p. 1-9

Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia

Dekker Linde, Calkoen Friso G., Jiang Yilin, Blok Hilly, Veldkamp Saskia R., De Koning Coco, Spoon Maike, Admiraal Rick, Hoogerbrugge Peter, Vormoor Britta, Vormoor H. Josef, Visscher Henk, Bierings Marc, Van Der Vlugt Marieke, Van Tinteren Harm, Nijstad A. Laura, Huitema Alwin D.R., Van Der Elst Kim C.M., Pieters Rob, Lindemans Caroline A., Nierkens Stefan 12 Apr 2022, In: Blood Advances. 6 , p. 1969-1976 8 p.

Ritonavir-Boosted Exposure of Kinase Inhibitors:an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib

Boosman René J, de Gooijer Cornedine J, Groenland Stefanie L, Burgers Jacobus A, Baas Paul, van der Noort Vincent, Beijnen Jos H, Huitema Alwin D R, Steeghs Neeltje Apr 2022, In: Pharmaceutical Research. 39 , p. 669-676 8 p.

Toxicity and efficacy of chronomodulated chemotherapy:a systematic review

Printezi Markella I, Kilgallen Aoife B, Bond Marinde J G, Štibler Urška, Putker Marrit, Teske Arco J, Cramer Maarten J, Punt Cornelis J A, Sluijter Joost P G, Huitema Alwin D R, May Anne M, van Laake Linda W Mar 2022, In: LANCET ONCOLOGY. 23 , p. e129-e143

Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity

Laoukili Jamila, Constantinides Alexander, Wassenaar Emma C E, Elias Sjoerd G, Raats Danielle A E, van Schelven Susanne J, van Wettum Jonathan, Volckmann Richard, Koster Jan, Huitema Alwin D R, Nienhuijs Simon W, de Hingh Ignace H J T, Wiezer René J, van Grevenstein Helma M U, Rinkes Inne H M Borel, Boerma Djamila, Kranenburg Onno 22 Feb 2022, In: British Journal of Cancer. 126 , p. 1824-1833 10 p.

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy in Children with Cancer:A Systematic Review and Meta-Analysis

Uittenboogaard Aniek, Neutel Céline L G, Ket Johannes C F, Njuguna Festus, Huitema Alwin D R, Kaspers Gertjan J L, van de Velde Mirjam E 1 Feb 2022, In: Cancers. 14 , p. 1-24

Everolimus Concentration in Saliva to Predict Stomatitis:A Feasibility Study in Patients with Cancer

Laura Molenaar-Kuijsten, Verheijen Remy B, Jacobs Bart A W, Bas Thijssen, Hilde Rosing, Dorlo Thomas P C, Beijnen Jos H, Neeltje Steeghs, Huitema Alwin D R 27 Jan 2022, In: Therapeutic drug monitoring. 44 , p. 520-526 7 p.

All research output

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