dr. A.T. (Titia) Lely

dr. A.T. (Titia) Lely

Associate Professor - medical
  • Birth Center Obstetrics - Medical

Research Programs



With the combination of a PhD in Nephrology (UMCG) and Post-doctoral training in preeclampsia field (Harvard), Titia Levy developed a unique translational research line with focus on the kidney during and after hypertensive-complicated pregnancies within Cardiovascular research line of the UMC Utrecht.

Her clinical work as gynaecologist in the Obstetrical department has its focus on Maternal Medicine and especially care for pregnancy in women with kidney disease. As young-PI, she works in close collaboration with the department of Nephrology, Vascular Medicine and Epidemiology (Julius Center). Furthermore, as a result of her post-doctoral period in Groningen several projects are in close collaboration with the UMCG.

It is her aim to improve patient care during and after pregnancy for cardiovascular and renal patients. With her translational research line mainly focussing on the kidney and vascular bed, she hopes to improve with research from bench to bedside and vice-versa renal and pregnancy outcomes in the long run.

Side Activities

Elective fellowship Maternal and Fetal Medicine at Mount Sinai Hospital

Fellowship and Awards

Dutch Kidney Foundation, Innovation grant, € 100.000 (2017)

ZonMW, Clinical fellowship, personal carrier grant € 160.000 (2013) 
Dutch Kidney Foundation, Kolff, personal junior post-doc grant € 170.000 (2011)
Personal MD/PhD Grant - UMCG - K. Holwerda - Hydrogen sulphide: a gas as therapy for PE?
(Lely: supervisor), 170.000 euro, co-PI (2011) 
Mandem Stipendium, personal post-doc grant UMCG € 100.000 (2010)
Personal MD/PhD Grant - UMCG - A.M. van der Graaf - Vascular and renal alterations in relation
to PE: from prediction to renal disease with focus on the AT-1 receptor (Lely: supervisor), 170.000 euro, co-PI (2010)

Research Output (49)

Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation-A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

Terstappen Fieke, Richter Anne E, Lely A Titia, Hoebeek Freek E, Elvan-Taspinar Ayten, Bos Arend F, Ganzevoort Wessel, Pels Anouk, Lemmers Petra M, Kooi Elisabeth M W 3 dec 2020, In: Frontiers in Pediatrics. 8 , p. 1-11

Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

Terstappen Fieke, Calis Jorg J A, Paauw Nina D, Joles Jaap A, van Rijn Bas B, Mokry Michal, Plösch Torsten, Lely A Titia dec 2020, In: Clinical Epigenetics. 12

Evaluating a cardiovascular disease risk management care continuum within a learning healthcare system:a prospective cohort study

Groenhof T Katrien J, Lely A Titia, Haitjema Saskia, Nathoe Hendrik M, Kortekaas Marlous F, Asselbergs Folkert W, Bots Michiel L, Hollander Monika, 17 nov 2020, In: BJGP Open. 4 , p. 1-10 10 p.

Prenatal Amino Acid Supplementation to Improve Fetal Growth:A Systematic Review and Meta-Analysis

Terstappen Fieke, Tol Angela J C, Gremmels Hendrik, Wever Kimberley E, Paauw Nina D, Joles Jaap A, Beek Eline M van der, Lely A Titia sep 2020, In: Nutrients. 12 , p. 1-55 55 p.

Preimplantation Genetic Testing for Monogenic Kidney Disease

Snoek Rozemarijn, Stokman Marijn F, Lichtenbelt Klaske D, van Tilborg Theodora C, Simcox Cindy E, Paulussen Aimée D C, Dreesen Jos C M F, van Reekum Franka, Lely A Titia, Knoers Nine V A M, de Die-Smulders Christine E M, van Eerde Albertien M 27 aug 2020, In: Clinical Journal of the American Society of Nephrology. 15 , p. 1279-1286 8 p.

Long-term renal disease after prematurity or fetal growth restriction: who is at risk?

Terstappen Fieke, Lely A Titia 28 jul 2020, In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 35 , p. 1087-1090 4 p.

Low-Density Lipoprotein Cholesterol Target Attainment in Patients With Established Cardiovascular Disease:Analysis of Routine Care Data

Groenhof T Katrien J, Kofink Daniel, Bots Michiel L, Nathoe Hendrik M, Hoefer Imo E, Van Solinge Wouter W, Lely A Titia, Asselbergs Folkert W, Haitjema Saskia 2 apr 2020, In: JMIR medical informatics. 8 , p. 1-12

Conflicting Effects of Fetal Growth Restriction on Blood Pressure Between Human and Animal Offspring: A Systematic Review and Meta-analysis

Kooiman Judith, Terstappen Fieke, van Wagensveld Lilian, Franx Arie, Wever Kimberley E., Roseboom Tessa J., Joles Jaap A., Gremmels Hendrik, Lely Titia A. mrt 2020, In: Hypertension. 27 , p. 320A-321A

Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia

Terstappen Fieke, Clarke Sinéad M, Joles Jaap A, Ross Courtney A, Garrett Michael R, Minnion Magdalena, Feelisch Martin, Goor Harry van, Sasser Jennifer M, Lely A Titia 1 feb 2020, In: Biomolecules. 10 14 p.

Conflicting Effects of Fetal Growth Restriction on Blood Pressure Between Human and Rat Offspring:A Meta-Analysis

Kooiman Judith, Terstappen Fieke, van Wagensveld Lilian, Franx Arie, Wever Kimberley E, Roseboom Tessa J, Joles Jaap A, Gremmels Hendrik, Lely A Titia 1 jan 2020, In: Hypertension (Dallas, Tex. : 1979). 75 , p. 806-818 13 p.

All research output

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