dr. ing. A.B. (Ynte) Kuypers

dr. ing. A.B. (Ynte) Kuypers

Associate Professor
dr. ing. A.B. (Ynte) Kuypers
  • Neurologen

Research Programs



My name is Ynte Ruigrok and I work as a stroke neurologist and an associate professor at the department of Neurology and Neurosurgery. Both in my clinical work and my research I focus on intracranial aneurysms. Intracranial aneurysms are present in 3% of the population and usually go undetected until rupture occurs leading to an often fatal aneurysmal subarachnoid hemorrhage (ASAH). The overall aim of my research is to identify the patients who are at high risk of developing aneurysms and a subsequent ASAH. It is my ambition to increase insight in underlying disease processes, improve detection of aneurysms in high risk patients and optimize treatment. My research has a strong translational view in which I combine genetics, epidemiology and imaging of intracranial aneurysms.

 For my research I have received several prestigious grants, including an ERC starting grant in 2019 for my research project PRYSM: Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage. This  project concerns translational research in which I integrate genetic and environmental risk factors with imaging markers and combine these factors in an aneurysm prediction risk model. This will lead to precision medicine in early aneurysm detection to reduce the burden of ASAH.

 To advance aneurysm genetic research I have initiated the intracranial aneurysm working group within the international stroke genetics consortium. This cohort enables me to provide insight in which genetic variants and/or genes are associated with intracranial aneurysms and thus make a major contribution to unravelling the genetic architecture of the disease. Recently a large scale genome wide association study (GWAS) on intracranial aneurysms was performed. Based on its findings now more than half of the disease heritability can be explained (Bakker et al, Nature Genetics 2020). Currently my group is performing translational research studies for understanding the biological mechanisms of genetic variants for intracranial aneurysms identified and for exploiting genetics for drug discovery. In addition, observational clinical studies are being performed which provide important insights into causality, mechanisms and consequences of genetic findings.

Research line

Genetic riks of stroke

Most recent key publications

1.  Zuurbier CC, ... , Ruigrok YM. Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis. Neurology. 2021 Oct 20:10.1212/WNL.0000000000012885. doi: 10.1212/WNL.0000000000012885

2. Bakker MK, Ruigrok YM. Genetics of Intracranial Aneurysms. Stroke. 2021 Aug;52(9):3004-3012. doi: 10.1161/STROKEAHA.120.032621. Epub 2021 Aug 17.

3. Bakker MK, … , Ruigrok YM. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nat Genet. 2020 Dec;52(12):1303-1313. doi: 10.1038/s41588-020-00725-7. Epub 2020 Nov 16.PMID: 33199917 

4. Bakker MK, Ettema RA, Klostermann M, Rinkel GJE, Veldink JH, Ruigrok YM. Role of Rare Genetic Variants Found in Families With Intracranial Aneurysms in the General Dutch and UK Population. Stroke. 2021 Aug;52(9):e540-e541. doi: 10.1161/STROKEAHA.121.035492. Epub 2021 Jun 25.PMID: 34167329

5. van 't Hof FNG, Lai D, van Setten J, Bots ML, Vaartjes I, Broderick J, Woo D, Foroud T, Rinkel GJE, de Bakker PIW, Ruigrok YM.Exome-chip association analysis of intracranial aneurysms. Neurology. 2020 Feb 4;94(5):e481-e488. doi: 10.1212/WNL.0000000000008665. Epub 2019 Nov 15.PMID: 31732565 

Fellowship and Awards

2020 Michele Sale award for Women in Stroke Genetics, an internationally competitive mid-career award of the Internation Stroke Genetics Consortium (ISGC)

2019 ERC starting grant from the European Research Council for the research project ‘Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid haemorrhage (PRYSM)

2014 ZonMW Clinical Fellowship for the research project ‘Towards therapeutic strategies for intracranial aneurysms through deep re-sequencing of genetic risk loci and comprehensive functional characterisation’ 

2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht

2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’

2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)

2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)

2005 personal grant from the Dr. E. Dekker program of the Duth Heart Foundation  for the research project 'The role of the extracellular matrix in intracranial aneurysms’ 

2000 personal grant from the program ‘AGIKO-stipendia’ of NWO for the PhD project on the genetic background of intracranial aneurysms and aneurysmal subarachnoid hemorrhage

Research Output (132)

Assessment of manual and automated intracranial artery diameter measurements

Vos Iris, Ruigrok Ynte, Velthuis Birgitta, Kuijf Hugo 21 Mar 2022,

The relation between urinary sodium and potassium excretion and risk of cardiovascular events and mortality in patients with cardiovascular disease

Groenland Eline H., Vendeville Jean Paul, Bots Michiel L., de Borst Gert Jan, Nathoe Hendrik M., Ruigrok Ynte M., Blankestijn Peter J., Visseren Frank L.J., Spiering Wilko Mar 2022, In: PLoS ONE. 17

Relationship between 3D Morphologic Change and 2D and 3D Growth of Unruptured Intracranial Aneurysms

Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Ruigrok Ynte, Velthuis Birgitta, van der Schaaf Irene Mar 2022, In: American Journal of Neuroradiology. 43 , p. 416-421 6 p.

Does the Internal Carotid Artery Attenuate Blood-Flow Pulsatility in Small Vessel Disease?:A 7 T 4D-Flow MRI Study

van Tuijl Rick J, Ruigrok Ynte M, Geurts Lennart J, van der Schaaf Irene C, Biessels Geert Jan, Rinkel Gabriël J E, Velthuis Birgitta K, Zwanenburg Jaco J M 2022, In: Journal of Magnetic Resonance Imaging.

Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases

Georges Adrien, Yang Min Lee, Berrandou Takiy Eddine, Bakker Mark K., Dikilitas Ozan, Kiando Soto Romuald, Ma Lijiang, Satterfield Benjamin A., Sengupta Sebanti, Yu Mengyao, Deleuze Jean François, Dupré Delia, Hunker Kristina L., Kyryachenko Sergiy, Liu Lu, Sayoud-Sadeg Ines, Amar Laurence, Brummett Chad M., Coleman Dawn M., d'Escamard Valentina, de Leeuw Peter, Fendrikova-Mahlay Natalia, Kadian-Dodov Daniella, Li Jun Z., Lorthioir Aurélien, Pappaccogli Marco, Prejbisz Aleksander, Smigielski Witold, Stanley James C., Zawistowski Matthew, Zhou Xiang, Zöllner Sebastian, Amouyel Philippe, De Buyzere Marc L., Debette Stéphanie, Dobrowolski Piotr, Drygas Wojciech, Gornik Heather L., Olin Jeffrey W., Piwonski Jerzy, Rietzschel Ernst R., Ruigrok Ynte M., Vikkula Miikka, Warchol Celinska Ewa, Januszewicz Andrzej, Kullo Iftikhar J., Azizi Michel, Jeunemaitre Xavier, Persu Alexandre, Kovacic Jason C., , , Dec 2021, In: Nature Communications. 12 , p. 1-16 1 p.

Difference in rupture risk between familial and sporadic intracranial aneurysms an individual patient data meta-analysis

Zuurbier Charlotte C.M., Mensing Liselore A., Wermer Marieke J.H., Juvela Seppo, Lindgren Antti E., Koivisto Timo, J¨äaskel¨ainen Juha E., Yamazaki Tomosato, Molenberg Rob, Van Dijk J. Marc C., Uyttenboogaart Maarten, Aalbers Marlien, Morita Akio, Tominari Shinjiro, Arai Hajime, Nozaki Kazuhiko, Murayama Yuichi, Ishibashi Toshihiro, Takao Hiroyuki, Rinkel Gabriel J.E., Greving Jacoba P., Ruigrok Ynte M. 30 Nov 2021, In: Neurology. 97 , p. E2195-E2203

Modifiable risk factors for intracranial aneurysm and aneurysmal subarachnoid hemorrhage:A mendelian randomization study

Karhunen Ville, Bakker Mark K., Ruigrok Ynte M., Gill Dipender, Larsson Susanna C. 16 Nov 2021, In: Journal of the American Heart Association. 10 , p. 1-8 8 p.

Sex Differences in Risk Profile, Stroke Cause and Outcome in Ischemic Stroke Patients With and Without Migraine

Linstra Katie M., van Os Hendrikus J.A., Ruigrok Ynte M., Nederkoorn Paul J., van Dijk Ewoud J., Kappelle L. Jaap, Koudstaal Peter J., Visser Marieke C., Ferrari Michel D., MaassenVanDenBrink Antoinette, Terwindt Gisela M., Wermer Marieke J.H., 3 Nov 2021, In: Frontiers in Neuroscience. 15 , p. 1-7 7 p.

Pulsatility attenuation along the carotid siphon in pseudoxanthoma elasticum

Bartstra J. W., van Tuijl R. J., de Jong P. A., Mali W. P.T.M., van der Schaaf I. C., Ruigrok Y. M., Rinkel G. J.E., Velthuis B. K., Spiering W., Zwanenburg J. J.M. 1 Nov 2021, In: American Journal of Neuroradiology. 42 , p. 2030-2033 4 p.

Reliability and Agreement of 2D and 3D Measurements on MRAs for Growth Assessment of Unruptured Intracranial Aneurysms

Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Otten Maarten, Ruigrok Ynte, Velthuis BK, van der Schaaf Irene 1 Sep 2021, In: American Journal of Neuroradiology. 42 , p. 1598-1603 6 p.

All research output

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