drs. X.Y.Y. (Pieter A.) Knevel

drs. X.Y.Y. (Pieter A.) Knevel

Full Professor
drs. X.Y.Y. (Pieter A.) Knevel
  • Division of Heart & Lungs



Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities


  • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
  • Chairman Steering committee Heart and Vascular Center  
  • Advisor AMT Utrecht
  • Advisor and shareholder HeartEye                                                                          

Fellowship and Awards



  • Fellow of the European Society of Cardiology, 2000
  • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
  • Visiting Professor Harvard University, USA, 2007-2009
  • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
  • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014


Research grants obtained 

  • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
  • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

  • NIH: "The role of the min K gene". Grant with R.S. Kass.

  • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

  • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

  • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

  • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

  • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

  • ICIN: Molecular genetic basis of cardiovascular disease (2000)

  • ICIN: Human genetics and cardiovascular developement (2000)

  • NHS: Dekker program: Vanessa van Empel (2001-2004)

  • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

  • BSIK: Weefsel op maat (2003)

  • Bekales Research Grant – Cardiology 2004, candidature.

  • Bekales Research Grant (2005)

  • NHS: Translational medicine: stem cell applications (2006)

  • ICIN: Stem cells from patients with genetic cardiac disease (2007)

  • BMM: SMARTCARE: cardiac repair with microtissues (2008)

  • NIRM: Stem cells as disease models (2009)

  • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
    Phase A1 preclinical PL €300.000 (total project  €2.0M)

  • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
    (Total project 0,5M)

  • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

  • Leducq (Total project 6 M€) (2018)

  • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (958)

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes

Yuan Qianliang, Maas Renee G.C., Brouwer Ellen C.J., Pei Jiayi, Blok Christian Snijders, Popovic Marko A., Paauw Nanne J., Bovenschen Niels, Hjortnaes Jesper, Harakalova Magdalena, Doevendans Pieter A., Sluijter Joost P.G., van der Velden Jolanda, Buikema Jan W. Feb 2022, In: Journal of Cardiovascular Development and Disease. 9 , p. 1-13

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel

van der Ven Casper F T, Tibbitt Mark W, Conde João, van Mil Alain, Hjortnaes Jesper, Doevendans Pieter A, Sluijter Joost P G, Aikawa Elena, Langer Robert S 28 Dec 2021, In: Nanoscale. 13 , p. 20451-20461 11 p.

Cardiovascular Morbidity and Mortality in Adult Patients With Repaired Aortic Coarctation

Meijs Timion A, Minderhoud Savine C S, Muller Steven A, de Winter Robbert J, Mulder Barbara J M, van Melle Joost P, Hoendermis Elke S, van Dijk Arie P J, Zuithoff Nicolaas P A, Krings Gregor J, Doevendans PAFM , Witsenburg Maarten, Roos-Hesselink Jolien W, van den Bosch Annemien E, Bouma Berto J, Voskuil Michiel 16 Nov 2021, In: Journal of the American Heart Association. 10

Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement

Wesselink Esther M., Abawi Masieh, Kooistra Nynke H. M., Kappen Teus H., Agostoni Pierfrancesco, Emmelot-Vonk Marielle, Pasma Wietze, Klei Wilton A., Jaarsveld Romy C., Dongen Charlotte S., Doevendans Pieter P. A. F. M., Slooter Arjen J. C., Stella Pieter R. Nov 2021, In: Journal of the American Geriatrics Society. 69 , p. 3177-3185 9 p.

Advanced image-supported lead placement in cardiac resynchronisation therapy:protocol for the multicentre, randomised controlled ADVISE trial and early economic evaluation

Wouters Philippe C, van Lieshout Chris, van Dijk Vincent F, Delnoy Peter-Paul Hm, Doevendans Pieter Afm, Cramer Maarten J, Frederix Geert Wj, van Slochteren Frebus J, Meine Mathias 25 Oct 2021, In: BMJ Open. 11 , p. 1-8

Randomised controlled trial into the role of ramipril in fibrosis reduction in rheumatic heart disease:The RamiRHeD trial protocol

Ambari Ade Meidian, Setianto Budhi, Santoso Anwar, Radi Basuni, Dwiputra Bambang, Susilowati Eliana, Tulrahmi Fadilla, Wind Annemiek, Cramer Maarten Jan Maria, Doevendans Pieter 13 Sep 2021, In: BMJ Open. 11 6 p.

Impaired right ventricular calcium cycling is an early risk factor in r14del-phospholamban arrhythmias

Haghighi Kobra, Gardner George, Vafiadaki Elizabeth, Kumar Mohit, Green Lisa C., Ma Jianyong, Crocker Jeffrey S., Koch Sheryl, Arvanitis Demetrios A., Bidwell Phillip, Rubinstein Jack, van de Leur Rutger, Doevendans Pieter A., Akar Fadi G., Tranter Michael, Wang Hong Sheng, Sadayappan Sakthivel, Demazumder Deeptankar, Sanoudou Despina, Hajjar Roger J., Stillitano Francesca, Kranias Evangelia G. Jun 2021, In: Journal of Personalized Medicine. 11 , p. 1-23

A Roadmap to Cardiac Tissue-Engineered Construct Preservation:Insights from Cells, Tissues, and Organs

Sampaio-Pinto Vasco, Janssen Jasmijn, Chirico Nino, Serra Margarida, Alves Paula M, Doevendans Pieter A, Voets Ilja K, Sluijter Joost P G, van Laake Linda W, van Mil Alain 28 May 2021, In: Advanced materials. 33 , p. 1-24

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

Lei Zhiyong, Wahlquist Christine, el Azzouzi Hamid, Deddens Janine C., Kuster Diederik, van Mil Alain, Rojas-Munoz Agustin, Huibers Manon M., Mercola Mark, de Weger Roel, Van der Velden Jolanda, Xiao Junjie, Doevendans Pieter A., Sluijter Joost P.G. 19 Mar 2021, In: Frontiers in cardiovascular medicine. 8 14 p.

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Maas Renee G.C., Lee Soah, Harakalova Magdalena, Snijders Blok Christian J.B., Goodyer William R., Hjortnaes Jesper, Doevendans Pieter A.F.M., Van Laake Linda W., van der Velden Jolanda, Asselbergs Folkert W., Wu Joseph C., Sluijter Joost P.G., Wu Sean M., Buikema Jan W. 19 Mar 2021, In: STAR protocols. 2

All research output

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