ir. F.G.G. Kierkels

ir. F.G.G. Kierkels

Associate Professor
ir. F.G.G. Kierkels
  • Department of Biostatistics and Research Support
  • Julius Center Research Program Methodology

Research Programs

Infection & Immunity



After years of being a concert pianist, Hae-Won Uh studied math as a hobby. She obtained MSc and PhD in Mathematical Statistics from University of Amsterdam. She has been working as a researcher in the multidisciplinary environment, specializing in Statistical Modeling and Data Science. She has been involved in various EU-funded projects: MIMOmics, BigData@Heart, IMforFUTURE, and MSA-Omics.

Her research focuses on the analysis of high-dimensional biological and medical data: specifically, statistical leaning with sparsity. In the era of big data, extracting hidden patterns from noisy heterogeneous data is essential but challenging. She develops methods for integrated analysis of various omics datasets (e.g. genetics, transcriptomics, metabolomics) to obtain more insight into biological mechanisms underlying traits. Such extracted patient-specific molecular profiles from multiple omics datasets will lead to better predictions of health outcomes.

Compositional data describe amounts of components of specimens, when the size of each specimen is constant; relative portions sum up to 100%. Because of this constraint of constant sum, direct applications of multivariate statistical methods may result in spurious conclusions. She develops statistical methods specifically for microbiome study: in particular, longitudinal models to fit the dynamic association among microbiome, environments and host.

A smartphone with a camera can detect heart rhythms, without medical assistance or additional instruments. She investigates the usage of  smartphone apps to acquires pulse waveforms via photoplethysmography (PPG). PPG is  related to cardiac-induced fluctuations in tissue blood volume using the built-in cameras and LED smartphone flash. She develops an algorithm to reconstruct the sharp spikes of a true ECG from a PPG record. This will lead to an efficient model that well discriminates an irregular pulse during AF from sinus rhythm.

Research Output (54)

Statistical integration of two omics datasets using GO2PLS

Gu Zhujie, El Bouhaddani Said, Pei Jiayi, Houwing-Duistermaat Jeanine, Uh Hae-Won Dec 2021, In: BMC Bioinformatics. 22 , p. 1-18

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20

Prediction of vascular aging based on smartphone acquired PPG signals

Dall'Olio Lorenzo, Curti Nico, Remondini Daniel, Safi Harb Yosef, Asselbergs Folkert W, Castellani Gastone, Uh Hae-Won Dec 2020, In: Scientific Reports. 10

Integration of high-dimensional omics data using sparse orthogonal 2-way partial least squares

Gu Zhujie, el Bouhaddani Said, Harakalova Magdalena, Houwing-Duistermaat Jeanine J., Uh Hae-Won Jul 2020, In: Genetic Epidemiology. 44 , p. 522-522

Statistical integration of methylation, transcriptome and proteome data in cell lines

Houwing-Duistermaat Jeanine J., el Bouhaddani Said, Uh Hae Won Jul 2020, In: Genetic Epidemiology. 44 , p. 489-489

Low IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency

Berbers Roos Marijn, Mohamed Hoesein Firdaus A.A., Ellerbroek Pauline M., van Montfrans Joris M., Dalm Virgil A.S.H., van Hagen P. Martin, Paganelli Fernanda L., Viveen Marco C., Rogers Malbert R.C., de Jong Pim A., Uh Hae Won, Willems Rob J.L., Leavis Helen L. 19 Jun 2020, In: Frontiers in Immunology. 11 11 p.

Choosing proper normalization is essential for discovery of sparse glycan biomarkers

Uh Hae-Won, Klarić Lucija, Ugrina Ivo, Lauc Gordan, Smilde Age K, Houwing-Duistermaat Jeanine J 25 Mar 2020, In: Molecular omics. 16 , p. 231-242 12 p.

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Klarić Lucija, Tsepilov Yakov A, Stanton Chloe M, Mangino Massimo, Sikka Timo Tõnis, Esko Tõnu, Pakhomov Eugene, Salo Perttu, Deelen Joris, McGurnaghan Stuart J, Keser Toma, Vučković Frano, Ugrina Ivo, Krištić Jasminka, Gudelj Ivan, Štambuk Jerko, Plomp Rosina, Pučić-Baković Maja, Pavić Tamara, Vilaj Marija, Trbojević-Akmačić Irena, Drake Camilla, Dobrinić Paula, Mlinarec Jelena, Jelušić Barbara, Richmond Anne, Timofeeva Maria, Grishchenko Alexander K, Dmitrieva Julia, Bermingham Mairead L, Sharapov Sodbo Zh, Farrington Susan M, Theodoratou Evropi, Uh Hae-Won, Beekman Marian, Slagboom Eline P, Louis Edouard, Georges Michel, Wuhrer Manfred, Colhoun Helen M, Dunlop Malcolm G, Perola Markus, Fischer Krista, Polasek Ozren, Campbell Harry, Rudan Igor, Wilson James F, Zoldoš Vlatka, Vitart Veronique, Spector Tim, Aulchenko Yurii S, Lauc Gordan, Hayward Caroline 19 Feb 2020, In: Science advances. 6 18 p.

Statistical method for modeling sequencing data from different technologies in longitudinal studies with application to Huntington disease

Fuady Angga M, van Roon-Mom Willeke M C, Kiełbasa Szymon M, Uh Hae-Won, Houwing-Duistermaat Jeanine J 2020, In: Biometrical Journal. 63 , p. 745-760 16 p.

Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of surgery type

Paganelli Fernanda L, Luyer Misha, Hazelbag C Marijn, Uh Hae-Won, Rogers Malbert R C, Adriaans Danielle, Berbers Roos-Marijn, Hendrickx Antoni P A, Viveen Marco C, Groot James A, Bonten Marc J M, Fluit Ad C, Willems Rob J L, Leavis Helen L 29 Jul 2019, In: Scientific Reports. 9

All research output

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