dr. mr. U.V. (Pauline) Keurhorst

dr. mr. U.V. (Pauline) Keurhorst

Assistant Professor
dr. mr. U.V. (Pauline) Keurhorst
  • Department of Epidemiology



Pauline Heus graduated as optometrist and orthoptist from the Hogeschool Utrecht in 2001. Until 2014 she worked at the ophthalmology department of Northwest Clinics in Alkmaar. Between 2006 and 2014 she actively contributed to the profession of optometry in the Netherlands as a board member of the Dutch Optometric Association (Optometristen Vereniging Nederland, OVN).

After obtaining a master’s degree in Evidence Based Practice (with distinction) at the University of Amsterdam, Pauline joined Cochrane Netherlands in 2011 (hosted by the Julius Center since 2014). Besides contributing to evidence syntheses and providing methodological support to authors of (Cochrane) systematic reviews, she is also involved in teaching. Her main research area of interest is the translation of evidence into clinical practice. In 2020, Pauline obtained her PhD degree at Utrecht University on a thesis titled "Maximizing research value: adequate reporting and effective (de-)implementation strategies". One of her research topics is the reporting of prediction model studies. Furthermore, she is involved in a program of the Netherlands Federation of University Medical Centers (NFU) about de-implementation of low-value care, called  ‘To do or not to do?’. 

Pauline is member of the Cochrane Bias Methods Group, Cochrane Knowledge Translation Working Group 'Growing Capacity in Users', and the international GRADE Working Group.


Research Output (39)

The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement

Vinkers Christiaan H, Lamberink Herm J, Tijdink Joeri K, Heus Pauline, Bouter Lex, Glasziou Paul, Moher David, Damen Johanna A, Hooft Lotty, Otte Willem M 19 Apr 2021, In: PLoS Biology. 19 , p. 1-16

Reducing Inappropriate Proton Pump Inhibitors Use for Stress Ulcer Prophylaxis in Hospitalized Patients:Systematic Review of De-Implementation Studies

Orelio Claudia C, Heus Pauline, Kroese-van Dieren Judith J, Spijker René, van Munster Barbara C, Hooft Lotty 2021, In: Journal of General Internal Medicine. 36 , p. 2065-2073 9 p.

Clinical utility of limited channel sleep studies versus polysomnography for obstructive sleep apnoea

van Doorn Sander, Heus Pauline, Damen Johanna A.A.G., Spijker Rene, Japenga Eva J., Reesink Herre, Scholten Rob J.P.M., Hooft Lotty 15 Dec 2020, In: Cochrane Database of Systematic Reviews. 2020 , p. 1-8

Strategies to reduce the use of low-value medical tests in primary care: a systematic review

Takada Toshihiko, Heus Pauline, van Doorn Sander, Naaktgeboren Christiana A., Weenink Jan-Willem, van Dulmen Simone A., Hooft Lotty 1 Dec 2020, In: British Journal of General Practice. 70 , p. E858-E865

Barriers and facilitators to reduce low-value care:a qualitative evidence synthesis

van Dulmen S A, Naaktgeboren C A, Heus Pauline, Verkerk Eva W, Weenink J, Kool Rudolf Bertijn, Hooft Lotty 30 Oct 2020, In: BMJ Open. 10 , p. 1-9

TRIPOD statement:a preliminary pre-post analysis of reporting and methods of prediction models

Zamanipoor Najafabadi Amir H, Ramspek Chava L, Dekker Friedo W, Heus Pauline, Hooft Lotty, Moons Karel G M, Peul Wilco C, Collins Gary S, Steyerberg Ewout W, van Diepen Merel 18 Sep 2020, In: BMJ Open. 10

Transparent Reporting of Multivariable Prediction Models in Journal and Conference Abstracts:TRIPOD for Abstracts

Heus Pauline, Reitsma Johannes B, Collins Gary S, Damen Johanna A A G, Scholten Rob J P M, Altman Douglas G, Moons Karel G M, Hooft Lotty 2 Jun 2020, In: Annals of Internal Medicine. 173 , p. 42-47 6 p.

Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease:A systematic review and meta-analysis

Damen Johanna A., Pajouheshnia Romin, Heus Pauline, Moons Karel G.M., Reitsma Johannes B., Scholten Rob J.P.M., Hooft Lotty, Debray Thomas P.A. 13 Jun 2019, In: BMC Medicine. 17

Uniformity in measuring adherence to reporting guidelines:The example of TRIPOD for assessing completeness of reporting of prediction model studies

Heus Pauline, Damen Johanna A.A.G., Pajouheshnia Romin, Scholten Rob J.P.M., Reitsma Johannes B., Collins Gary S., Altman Douglas G., Moons Karel G.M., Hooft Lotty 24 Apr 2019, In: BMJ Open. 9

All research output

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