drs. R.S. (Raymond) Huis

drs. R.S. (Raymond) Huis

Full Professor
drs. R.S. (Raymond) Huis
  • Central Diagnostic Laboratory



Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.


Side Activities

Without remuneration

President European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles & Drug Delivery and Translational Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board Anjarium BioSciences

Member Scientific Advisory Board SentryX bv 



Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release


Part-time employment

Nanocell Therapeutics BV

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

Research Output (170)

Utilizing in vitro drug release assays to predict in vivo drug retention in micelles

Varela-Moreira Aida, van Leur Heleen, Krijgsman Danielle, Ecker Veronika, Braun Martina, Buchner Maike, Fens Marcel H A M, Hennink Wim E, Schiffelers Raymond M 25 Apr 2022, In: International Journal of Pharmaceutics. 618

VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow

van Moorsel Marc V A, Poolen Geke, Koekman Cornelis A, Verhoef Sandra, de Maat Steven, Barendrecht Arjan, van Kleef Nadine D, Meijers Joost C M, Schiffelers Raymond, Maas Coen, Urbanus Rolf T 16 Feb 2022, In: Journal of thrombosis and haemostasis : JTH. 20 , p. 1213-1222 10 p.

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement

Senti Mariona Estape, de Jongh Caroline A., Dijkxhoorn Kim, Verhoef Johan J. F., Szebeni Janos, Storm Gert, Hack C. Erik, Schiffelers Raymond M., Fens Marcel H., Boross Peter 7 Dec 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 341 , p. 475-486 12 p.

Themed issue:Extracellular vesicles in drug delivery and bioengineering

Fuhrmann Gregor, Lehr Claus-Michael, Schiffelers Raymond 1 Dec 2021, In: Advanced Drug Delivery Reviews. 181

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

van Haren Matthijs J, Gao Yongzhi, Buijs Ned, Campagna Roberto, Sartini Davide, Emanuelli Monica, Mateuszuk Lukasz, Kij Agnieszka, Chlopicki Stefan, Escudé Martinez de Castilla Pol, Schiffelers Raymond, Martin Nathaniel I 14 Sep 2021, In: Biomolecules. 11

Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Kooijmans Sander A A, de Jong Olivier G, Schiffelers Raymond M Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 252-278 27 p.

Extracellular vesicles as a drug delivery system:A systematic review of preclinical studies

Escudé Martinez de Castilla Pol, Tong Lingjun, Huang Chenyuan, Sofias Alexandros Marios, Pastorin Giorgia, Chen Xiaoyuan, Storm Gert, Schiffelers Raymond M, Wang Jiong-Wei 18 May 2021, In: Advanced Drug Delivery Reviews. 175 , p. 1-39

Preface Special Issue (Sung Wan Kim memorial, Journal of Controlled Release)

Grainger David W, Hennink Wim, Schiffelers Raymond, Bae You Han 10 Apr 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 332 , p. 592-593 2 p.

Natural or Synthetic RNA Delivery:A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Murphy Daniel E, de Jong Olivier G, Evers Martijn J W, Nurazizah Maratussholikhah, Schiffelers Raymond M, Vader Pieter 11 Feb 2021, In: Nano letters. 21 , p. 1888-1895 8 p.

Polymeric delivery systems for nucleic acid therapeutics:Approaching the clinic

van den Berg Annette I S, Yun Chae-Ok, Schiffelers Raymond M, Hennink Wim E 13 Jan 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 331 , p. 121-141 21 p.

All research output

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