drs. X.Y.Y. Hagendoorn
drs. X.Y.Y. Hagendoorn
- Department of Pathology
Research Programs
Biography
Biography
Dr. Sabine Linn is a professor of translational oncology focusing on breast cancer at Utrecht University, The Netherlands. Linn received her medical degree (1991, cum laude) at the State University Leiden, The Netherlands, and her internal medicine board certification (2000) at the University Medical Center Utrecht, The Netherlands. She earned her PhD (1998) on the subject of multidrug resistance in solid tumors from the Free University of Amsterdam under supervision of prof. Dr H.M. Pinedo.
She was awarded a Dutch Cancer Society Research Fellowship in 2000 and developed two conditional knock-out mouse models, one for non-small cell lung cancer and one for small cell lung cancer, respectively, in close collaboration with Dr Ralph Meuwissen in the laboratory of prof. Dr A.J. Berns at the Netherlands Cancer Institute, Amsterdam, The Netherlands. From 2001 to 2002 she was a postdoctoral research fellow in the laboratories of prof. Dr P.O. Brown, and prof. Dr M. van de Rijn, at Stanford University Medical School, Stanford, CA, where she contributed to the development of a molecular classification for soft tissue sarcomas. She returned to the Netherlands Cancer Institute in Amsterdam, where she earned her medical oncology certification (2002-2005) and became a senior staff member of the Division of Medical Oncology (2003).
Since 2005 she has also been a group leader at the Division of Molecular Pathology at the Netherlands Cancer Institute where she and her research group focus on the molecular dissection of breast cancer by differential drug sensitivity. To further develop this research line Dr. Linn was awarded a Dutch Cancer Society Clinical Research Award in 2006. From 2008-2012, Dr Linn served as chair of the Working Group on (neo)adjuvant systemic therapy of the Dutch Breast Cancer Trialists' Group (BOOG).
Side Activities
Neven activiteiten van Sabine Linn
Family Name:
Linn
Christian names:
Sabine Charlotte
BIG number:
99032942301
Working address:
Dept. of Medical Oncology
Netherlands Cancer Institute
Plesmanlaan 121
1066 CX Amsterdam
The Netherlands
Telephone:
+31 20 5129111
Fax:
+31 20 5122572
Advisory boards and consultancies
2012 – present
Function: Member Scientific Advisory Board
Organization: Cergentis, a spin-off company for targeted amplification of complete genes, The Netherlands
Personal income: No
2016
Function: Member Lynparza (Olaparib) AstraZeneca Global Advisory Board
Organization: AstraZeneca
Personal income: No
2016 – 2017
Function: Member IBM Watson Health Oncology Global Advisory Board
Organization: IBM, Boston, MA, USA
Personal income: No
Educational and scientific committees
2003 – 2020
Function: Member of the NKI-AVL Organizing Committee for Continuing Medical Education Program for Dutch Medical Oncologists “DONAMO (DOorlopende NAscholing Medische Oncologie)”
Organization: Netherlands Cancer Institute, Amsterdam, Netherlands
Personal income: No
2007 – 2015
Function: Member of the Dutch Society for Medical Oncology (NVMO) Advisory Board for the Dutch Institute for Healthcare Improvement (CBO) Breast Cancer Guidelines
Organization: Dutch Institute for Healthcare Improvement (CBO)
Personal income: No
2008 – 2013
Function: Chair Working Group (neo)adjuvant systemic therapy of Borstkanker Onderzoek Groep (BOOG) (Dutch Breast Cancer Trialists’ Group)
Organization: Dutch Breast Cancer Trialists’ Group
Personal income: No
2013 – 2019
Function: Member of Program Committee of Dutch and Flemish Annual Oncology Days (NVMO Oncologiedagen Nederland en Vlaanderen)
Organization: NVMO (Nederlandse Vereniging voor Medische Oncologie)
Personal income: No
2014 – present
Function: Member Committee on Personalised Medicine
Organization: ZonMw, The Netherlands
Personal income: No
2015 - present
Member Editorial Board of Breast Cancer Research
Organization: Springer Nature
Personal income: No
2015
Function: Member Scientific Advisory Group
Organization: European Medicines Agency (EMA) London, UK
Personal income: No
2016 – 2017
Function: Member RiskAp Expert Group on breast cancer screening
Organization: German Federal Ministry of Education and Research
Personal income: No
2016 – 2017
Function: Member Scientific Evaluation Committee Institut National du Cancer, France
Organization: Institut National du Cancer (INCA), Paris, France
Personal income: No
2016 – 2017
Function: Member Expert Review Panel CRUK and EPSRC Cancer Imaging Centres (Oxford University, Cambridge University, King’s College London/University College London, The Institute of Cancer Research)
Organization: Cancer Research United Kingdom (CRUK)
Personal income: No
2016 – 2017
Function: Member IMPAKT 2017 Scientific Committee, Brussels, Belgium
Organization: ESMO (European Society of Medical Oncology) and BIG (Breast International Group)
Personal income: No
2016 – 2018
Function: Member ESMO 2018 scientific subcommittee breast cancer, early
Organization: ESMO (European Society of Medical Oncology)
Personal income: No
2017 – 2019
Function: Co-chair (with Alberto Bardelli) ESMO-EACR 2019 scientific subcommittee Translational Research
Organization: ESMO (European Society of Medical Oncology)
Personal income: No
2017 – 2020
Function: Member evaluation board of the panel LS4 “Physiology, Pathophysiology and Endocrinology” for European Research Council Consolidator Grants (CoG) in 2018, and 2020
Organization: European Commission
Personal income: Yes, > 2,200 Euro/year
2021 – present
Function: Member VIDI committee Dutch Research Council (NWO)
Organisation: Dutch Research Council (NWO)
Personal income: yes, < 2,200 euro/year
Research Output (114)
de Wild Sabine R., de Munck Linda, Simons Janine M., Verloop Janneke, van Dalen Thijs, Elkhuizen Paula H.M., Houben Ruud M.A., van Leeuwen A. Elise, Linn Sabine C., Pijnappel Ruud M., Poortmans Philip M.P., Strobbe Luc J.A., Wesseling Jelle, Voogd Adri C., Boersma Liesbeth J. Sep 2022, In: The Lancet Oncology. 23 , p. 1201-1210 10 p.
Suelmann B. B.M., Bakhuis C. F.J., van Dooijeweert C., Verloop J., Zweemer R., Linn S., van der Wall E., van Diest P. J. 2022, In: Breast Cancer Research and Treatment. 192 , p. 175-189 15 p.
van Rossum Annelot G J, Mandjes Ingrid A M, van Werkhoven Erik, van Tinteren Harm, van Leeuwen-Stok A Elise, Nederlof Petra, Portielje Johanna E A, van Alphen Robbert J, Platte Els, van den Broek Daan, Huitema Alwin, Kok Marleen, Linn Sabine C, Oosterkamp Hendrika M 1 Dec 2021, In: Breast care (Basel, Switzerland). 16 , p. 598-606 9 p.
El Bairi Khalid, Haynes Harry R., Blackley Elizabeth, Fineberg Susan, Shear Jeffrey, Turner Sophia, de Freitas Juliana Ribeiro, Sur Daniel, Amendola Luis Claudio, Gharib Masoumeh, Kallala Amine, Arun Indu, Azmoudeh-Ardalan Farid, Fujimoto Luciana, Sua Luz F., Liu Shi Wei, Lien Huang Chun, Kirtani Pawan, Balancin Marcelo, El Attar Hicham, Guleria Prerna, Yang Wenxian, Shash Emad, Chen I. Chun, Bautista Veronica, Do Prado Moura Jose Fernando, Rapoport Bernardo L., Castaneda Carlos, Spengler Eunice, Acosta-Haab Gabriela, Frahm Isabel, Sanchez Joselyn, Castillo Miluska, Bouchmaa Najat, Md Zin Reena R., Shui Ruohong, Onyuma Timothy, Yang Wentao, Husain Zaheed, Willard-Gallo Karen, Coosemans An, Perez Edith A., Provenzano Elena, Ericsson Paula Gonzalez, Richardet Eduardo, Mehrotra Ravi, Sarancone Sandra, Ehinger Anna, Linn Sabine, Van Diest Paul J., Dec 2021, In: npj Breast Cancer. 7
Bakhuis Carsten F. J., Suelmann Britt B. M., van Dooijeweert Carmen, Linn Sabine, van der Wall Elsken, van Diest Paul J. Dec 2021, In: Critical Reviews in Oncology Hematology. 168
Dackus Gwen M H E, Jóźwiak Katarzyna, Sonke Gabe S, van der Wall Elsken, van Diest Paul J, Siesling Sabine, Hauptmann Michael, Linn Sabine C 2 Nov 2021, In: Journal of the National Cancer Institute. 113 , p. 1506-1514 9 p.
Joosten Stacey E.P., Wellenstein Marius, Koornstra Rutger, van Rossum Annelot, Sanders Joyce, van der Noort Vincent, Ferrandez Maria C., Harkes Rolf, Mandjes Ingrid A.M., Rosing Hilde, Huitema Alwin, Beijnen Jos H., Wesseling Jelle, van Diest Paul J., Horlings Hugo M., Linn Sabine C., Zwart Wilbert 20 Oct 2021, In: npj Breast Cancer. 7 , p. 1-8
Ragusi Max Aa, Winter-Warnars Gonneke Ao, Wesseling Jelle, Linn Sabine C., Beets-Tan Regina G., van der Velden Bas Hm, Elias Sjoerd G., Gilhuijs Kenneth Ga, Loo Claudette E. 1 Jul 2021, In: The British journal of radiology. 94 , p. 1-10 10 p.
Geenen Jill J J, Dackus Gwen M H E, Schouten Philip C, Pluim Dick, Marchetti Serena, Sonke Gabe S, Jóźwiak Katarzyna, Huitema Alwin D R, Beijnen Jos H, Schellens Jan H M, Linn Sabine C 15 Jun 2021, In: International Journal of Cancer. 148 , p. 3041-3050 10 p.
van der Meer Daniël J., Kramer Iris, van Maaren Marissa C., van Diest Paul J., C. Linn Sabine, Maduro John H., J.A. Strobbe Luc, Siesling Sabine, Schmidt Marjanka K., Voogd Adri C. 1 May 2021, In: International Journal of Cancer. 148 , p. 2289-2303 15 p.