Back

dr. F. (Floris) Groenendaal

dr. F. (Floris) Groenendaal

Associate Professor - medical
dr. F. (Floris) Groenendaal
  • Birth Center Neonatology - Medical

Biography

Biography

Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

•          Invited speaker on many international courses and symposia

•          Co-inventor of 2-iminobiotin for neonatal neuroprotection

•          Expert witness in several legal cases

•          Reviewer for many international scientific journals

Fellowship and Awards

- Ter Meulen Fonds, KNAW, Amsterdam 1993

- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

- NWO AGIKO-stipendium 920-03-039

- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

- Dr.W.M.Phelps-Stichting voor Spastici 03.016

- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (577)

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Eijsermans Rian M J C, Mocking Manouk, van Schooneveld Monique M J, Dudink Jeroen, van Straaten Henrica L M, Benders Manon J N L, Lequin Maarten, van der Aa Niek E dec 2021, In: Scientific Reports. 11 , p. 5017

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy:A Systematic Review for Future Research

Kleuskens Dianne G, Gonçalves Costa Filipe, Annink Kim V, van den Hoogen Agnes, Alderliesten Thomas, Groenendaal Floris, Benders Manon J N, Dudink Jeroen 2 feb 2021, In: Frontiers in Pediatrics. 9 , p. 631258

Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants

Coviello Caterina, Perrone Serafina, Buonocore Giuseppe, Negro Simona, Longini Mariangela, Dani Carlo, de Vries Linda S, Groenendaal Floris, Vijlbrief Daniel C, Benders Manon J N L, Tataranno Maria Luisa 15 jan 2021, In: Frontiers in Pediatrics. 8 , p. 618622

Background incidence rates of adverse pregnancy outcomes in the Netherlands:Data of 2006-2018

Immink Maarten M, Koole Sanne, Bekker Mireille N, Groenendaal Floris, Kemmeren Jeanet M, de Melker Hester E, van der Maas Nicoline A T jan 2021, In: European Journal of Obstetrics, Gynecology and Reproductive Biology. 256 , p. 274-280 7 p.

Association of early skin breaks and neonatal thalamic maturation:A modifiable risk?

Duerden Emma G, Grunau Ruth E, Chau Vann, Groenendaal Floris, Guo Ting, Chakravarty M Mallar, Benders Manon, Wagenaar Nienke, Eijsermans Rian, Koopman Corine, Synnes Anne, Vries Linda de, Miller Steven P 21 okt 2020, In: Neurology. 95 , p. e3420-e3427

Prognostic models versus single risk factor approach in first trimester selective screening for gestational diabetes mellitus:a prospective population-based multicentre cohort study

van Hoorn Fieke, Ph Koster Maria, Naaktgeboren Christiana A, Groenendaal Floris, Kwee Anneke, Lamain-de Ruiter Marije, Franx Arie, Bekker Mireille N 1 sep 2020, In: BJOG - An International Journal of Obstetrics and Gynaecology. 128 , p. 645-654 10 p.

Increased Use of Therapeutic Hypothermia in Infants with Milder Neonatal Encephalopathy due to Presumed Perinatal Asphyxia

Parmentier Corline E J, de Vries Linda S, Toet Mona C, van Haastert Ingrid C, Koopman Corine, Weeke Lauren C, Groenendaal Floris 19 aug 2020, In: Neonatology. 117 , p. 488-494 7 p.

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation:Outcome at 2 Years

Cizmeci Mehmet N, Groenendaal Floris, Liem Kian D, van Haastert Ingrid C, Benavente-Fernández Isabel, van Straaten Henrica L M, Steggerda Sylke, Smit Bert J, Whitelaw Andrew, Woerdeman Peter, Heep Axel, de Vries Linda S, 12 aug 2020, In: The Journal of Pediatrics. 226 , p. 28-35.e2

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink Kim, V, Groenendaal Floris, Cohen Daan, van der Aa Niek E., Alderliesten Thomas, Dudink Jeroen, Benders Manon J. N. L., Wijnen Jannie P. 1 aug 2020, In: Pediatric Research. 88 , p. 279-284 6 p.

Introduction of Ultra-High-Field MR Imaging in Infants:Preparations and Feasibility

Annink K V, van der Aa N E, Dudink J, Alderliesten T, Groenendaal F, Lequin M, Jansen F E, Rhebergen K S, Luijten P, Hendrikse J, Hoogduin H J M, Huijing E R, Versteeg E, Visser F, Raaijmakers A J E, Wiegers E C, Klomp D W J, Wijnen J P, Benders M J N L 30 jul 2020, In: American Journal of Neuroradiology. 41 , p. 1532-1537 6 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht

Contact

Emergency?

Directions

Appointments

Practical

umcutrecht.nl maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet