prof. dr. J.C. (Hans) Clevers

prof. dr. J.C. (Hans) Clevers

Full Professor
prof. dr. J.C. (Hans) Clevers
  • Molecular Cancer Research
  • Hubrecht Institute



Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

Honorary professorship:

2002 –  Honorary professor at Changsha-Hunan, China



Member European Molecular Biology Organisation (EMBO)

Member of the Royal Netherlands Academy of Sciences

Member of the International Society for Stem Cell Research (ISSCR)

Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

Member of the American Association for Cancer Research (AACR)

Member of the National Scientific Advisory Board NKI-AVL

Member of the scientific advisory board of “de Anatomische Les”

Member of the Academia Europaea

Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

Member of the American Academy of Arts and Sciences

Member of the The Royal Holland Society of Sciences and Humanities

Member of the Gairdner Foundation medical advisory board

Foreign Associate of the US National Academy of Sciences

Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology


He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Fellowship and Awards

2000     Catharijne-prize for medical science

2001     Award from the European Society for Clinical Investigation

2001     Spinoza-award

2004     Louis-Jeantet Prize for Medicine

2005     The Science and Society Prize

2005     The French honor of “Chevalier de la Legion d'Honneur”

2005     Katharine Berkan Judd Award

2006     Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2008     Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2008     Meyenburg Cancer Research Award

2009     The Queen Wilhelmina Dutch Cancer Society Award

2010     The United European Gastroenterology Federation (UEGF) Research Prize

2011     The Ernst Jung Medical Award

2011     Kolff prize

2012     Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2012     William Beaumont prize of the American Gastroenterology Association

2012     The Heineken Prize for Medicine

2012     Ridder in de Orde van de Nederlandse Leeuw

2013     The Breakthrough Prize in Life Sciences

2014     Massachusetts General Hospital Award in Cancer Research

2014     TEFAF Oncology Chair 2014

2014     Fellow of the AACR Academy

2014     Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014     National Icon 2014

Research Output (567)

The frontier of live tissue imaging across space and time

Huang Qiang, Garrett Aliesha, Bose Shree, Blocker Stephanie, Rios Anne C, Clevers Hans, Shen Xiling 1 apr 2021, In: Cell stem cell. 28 , p. 603-622 20 p.

Author Correction:Fasting-mimicking diet and hormone therapy induce breast cancer regression

Caffa Irene, Spagnolo Vanessa, Vernieri Claudio, Valdemarin Francesca, Becherini Pamela, Wei Min, Brandhorst Sebastian, Zucal Chiara, Driehuis Else, Ferrando Lorenzo, Piacente Francesco, Tagliafico Alberto, Cilli Michele, Mastracci Luca, Vellone Valerio G, Piazza Silvano, Cremonini Anna Laura, Gradaschi Raffaella, Mantero Carolina, Passalacqua Mario, Ballestrero Alberto, Zoppoli Gabriele, Cea Michele, Arrighi Annalisa, Odetti Patrizio, Monacelli Fiammetta, Salvadori Giulia, Cortellino Salvatore, Clevers Hans, De Braud Filippo, Sukkar Samir G, Provenzani Alessandro, Longo Valter D, Nencioni Alessio 24 dec 2020, In: Nature. 588 , p. E33-E33

Establishment of Pancreatic Organoids from Normal Tissue and Tumors

Driehuis Else, Gracanin Ana, Vries Robert Gerhardus Jacob, Clevers Hans, Boj Sylvia Fernández 18 dec 2020, In: STAR protocols. 1 , p. 1-32

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen Monique M A, Roos Floris J M, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Bijvelds Marcel J C, de Jonge Hugo R, Ardisasmita Arif I, van Huizen Nick A, Roest Henk P, de Jonge Jeroen, Koch Michael, Pampaloni Francesco, Fuchs Sabine A, Schene Imre F, Luider Theo M, van der Doef Hubert P J, Bodewes Frank A J A, de Kleine Ruben H J, Spee Bart, Kremers Gert-Jan, Clevers Hans, IJzermans Jan N M, Cuppen Edwin, van der Laan Luc J W 14 dec 2020, In: Scientific Reports. 10 , p. 1-16 16 p.

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Demmers Laura C, Kretzschmar Kai, Van Hoeck Arne, Bar-Epraïm Yotam E, van den Toorn Henk W P, Koomen Mandy, van Son Gijs, van Gorp Joost, Pronk Apollo, Smakman Niels, Cuppen Edwin, Clevers Hans, Heck Albert J R, Wu Wei 1 dec 2020, In: Nature Communications. 11 , p. 1-10

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/beta-catenin pathway activation

Cho Yong-Hee, Ro Eun Ji, Yoon Jeong-Su, Mizutani Tomohiro, Kang Dong-Woo, Park Jong-Chan, Il Kim Tae, Clevers Hans, Choi Kang-Yell 1 dec 2020, In: Nature Communications. 11

Human-Derived Model Systems in Gynecological Cancer Research

Lõhmussaar Kadi, Boretto Matteo, Clevers Hans dec 2020, In: Trends in Cancer. 6 , p. 1031-1043 13 p.

Hepatocyte growth factor/MET and CD44 in colorectal cancer:partners in tumorigenesis and therapy resistance

Joosten Sander P.J., Spaargaren Marcel, Clevers Hans, Pals Steven T. dec 2020, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1874 , p. 188437

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Yan Helen H N, Siu Hoi Cheong, Ho Siu Lun, Yue Sarah S K, Gao Yang, Tsui Wai Yin, Chan Dessy, Chan April S, Wong Jason W H, Man Alice H Y, Lee Bernard C H, Chan Annie S Y, Chan Anthony K W, Hui Ho Sang, Cheung Arthur K L, Law Wai Lun, Lo Oswens S H, Yuen Siu Tsan, Clevers Hans, Leung Suet Yi dec 2020, In: Gut. 69 , p. 2165-2179 15 p.

Translation and Replication Dynamics of Single RNA Viruses

Boersma Sanne, Rabouw Huib H, Bruurs Lucas J M, Pavlovič Tonja, van Vliet Arno L W, Beumer Joep, Clevers Hans, van Kuppeveld Frank J M, Tanenbaum Marvin E 6 nov 2020, In: Cell. 183 , p. 1930-1945 e1-13

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet