prof. dr. A.L. (A.L.) Bredenoord

prof. dr. A.L. (A.L.) Bredenoord

Full Professor
prof. dr. A.L. (A.L.) Bredenoord
  • Department of Public Health, Healthcare Innovation & Evaluation and Medical Humanities (PHM)
  • Julius Center Research Program Methodology



Prof dr Annelien Bredenoord is a professor of Ethics of Biomedical Innovation at the University Medical Center Utrecht. Her research, consultancy and teaching is focused on the ethical issues in emerging biomedical technology and translational medicine.

She is particularly fascinated by the rapid developments in genetics/genomics, regenerative medicine, stem cell research, biobanking, surgical innovation, Big Data and the associated ethical and societal challenges: how to translate biomedical innovations from basic research into clinical care and society in an ethically sound way?

She published widely in those fields and is member of several (inter)national committees among which the Ethics Committee of the International Society for Stem Cell Research (ISSCR), The Young Academy of the Royal Netherlands Academy of Arts and Sciences (KNAW), The Young Health Council, The National Indication Committee Preimplantation Genetic Diagnosis, The NIAS Lorenz Advisory Board, L 'Oreal UNESCO For Women in Science program, and UMC Utrecht’s Research Ethics Committee (METC).

She obtained a VENI grant to study the ethics of translational stem cell research and supervises several PhD-students and medical students. She teaches ethics at the Medical School of Utrecht University.

Annelien has been political active for the Dutch social-liberal party D66 for 15 years. As of 2015, she is member of the Dutch Senate (Eerste Kamer) on behalf of D66.

Side Activities

- International Society for Stem Cell Research (ISSCR): Chair of the Ethics Committee (2016 - ongoing)      

-    International Stem Cell Forum (ISCF): Ethics Working Party (2011 - ongoing)

-          European Meeting on Psycho-Social Aspects of Genetics (EMPAG): Scientific Board (2014 - ongoing)

-          NIAS Lorentz Advisory Board (2015 – ongoing)

-          The Royal Netherlands Academy of Arts and Sciences (KNAW): The Young Academy (De Jonge Akademie) (2014-2019)

-          Dutch Association for Clinical Genetics: Ethics Committee (2013 – ongoing)

-          National Indication Committee for Preimplantation Genetic Diagnosis (2012 – ongoing)

-          Member Research Ethics Committee (METC) UMC Utrecht

-          Member of UMC Utrecht Ethics Committee on Reproductive Medicine

-          September 2008: Academic Visitor at the Mitochondrial Research Group, the Medical School, University of Newcastle-upon-Tyne, UK

Fellowship and Awards

-          Dutch Cancer Society KWF grant: “An empirical ethics study to introduce next-generation DNA sequencing into cancer care in a responsible way” (2014-2017)

-          University Medical Center Utrecht Strategic Program Associate Professorship grant (2014)

-          The Netherlands Organisation for Health Research and Development ZonMw VENI grant: “Ethics of translational stem cell research: moving pluripotent stem cells to the clinic” (2012-2015)

-          BioMedical Materials Program (BMM): “Regenerative Medicine and early intervention in intervertebral disc disease: ethics from bench to bedside” (2011-2014)

-          The Netherlands Organisation for Health Research and Development ZonMw Program Priority Medicines for Children: “To store or not to store? A normative analysis of consent in pediatric biobanks” ((2011-2014)

-          The Netherlands Organisation for Health Research and Development ZonMw Program Ethics & Health Care: “Research ethics in genomics studies: towards a protocol for returning individual genetic data to research participants” (2010-2011)

-          European Neuromuscular Centre International Workshop: grant to organize an international expert meeting: the 174th ENMC international workshop on Applying Pre-implantation Genetic Diagnosis to mtDNA disease” (Naarden, 19-21 March, 2010)

Research Output (117)

Modeling human embryogenesis: embryo-like structures spark ethical and policy debate:embryo-like structures spark ethical and policy debate

Pereira Daoud Ana M, Popovic Mina, Dondorp Wybo J, Trani Bustos Marc, Bredenoord Annelien L, Chuva de Sousa Lopes Susana M, van den Brink Susanne C, Roelen Bernard A J, de Wert Guido M W R, Heindryckx Björn 1 nov 2020, In: Human Reproduction Update. 26 , p. 779-798 20 p.

Ethics parallel research:An approach for (early) ethical guidance of biomedical innovation

Jongsma Karin R., Bredenoord Annelien L. 1 sep 2020, In: BMC Medical Ethics. 21

User Experiences With and Recommendations for Mobile Health Technology for Hypertensive Disorders of Pregnancy:Mixed Methods Study

Jongsma Karin Rolanda, van den Heuvel Josephus F M, Rake Jasmijn, Bredenoord Annelien L, Bekker Mireille N 4 aug 2020, In: JMIR mHealth and uHealth. 8

Ethical challenges for pediatric liver organoid transplantation

Schneemann Sarah A, Boers Sarah N, van Delden Johannes J M, Nieuwenhuis Edward E S, Fuchs Sabine A, Bredenoord Annelien L 15 jul 2020, In: Science translational medicine. 12 , p. 1-3

Preferences to receive unsolicited findings of germline genome sequencing in a large population of patients with cancer

Bijlsma Rhode, Wouters Roel, Wessels Hester, Sleijfer Stefan, Beerepoot Laurens, Ten Bokkel Huinink Daan, Cruijsen Hester, Heijns Joan, Lolkema Martijn P, Steeghs Neeltje, van Voorthuizen Theo, Vulink Annelie, Witteveen Els, Ausems Margreet, Bredenoord Annelien, May Anne M, Voest Emile apr 2020, In: ESMO open. 5 9 p.

Responsible use of organoids in precision medicine:The need for active participant involvement

Lensink Michael A., Jongsma Karin R., Boers Sarah N., Noordhoek Jacquelien J., Beekman Jeffrey M., Bredenoord Annelien L. apr 2020, In: Development (Cambridge). 147

European guidelines on achalasia:United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations

Oude Nijhuis R. A.B., Zaninotto G., Roman S., Boeckxstaens G. E., Fockens P., Langendam M. W., Plumb A. A., Smout A. J.P.M., Targarona E. M., Trukhmanov A. S., Weusten B. L.A.M., Bredenoord A. J. 1 feb 2020, In: United European Gastroenterology Journal. 8 , p. 13-33 21 p.

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky Nikolaus, Almouzni Geneviève, Gorski Stanislaw A., Aerts Stein, Amit Ido, Bertero Michela G., Bock Christoph, Bredenoord Annelien L., Cavalli Giacomo, Chiocca Susanna, Clevers Hans, De Strooper Bart, Eggert Angelika, Ellenberg Jan, Fernández Xosé M., Figlerowicz Marek, Gasser Susan M., Hubner Norbert, Kjems Jørgen, Knoblich Jürgen A., Krabbe Grietje, Lichter Peter, Linnarsson Sten, Marine Jean Christophe, Marioni John, Marti-Renom Marc A., Netea Mihai G., Nickel Dörthe, Nollmann Marcelo, Novak Halina R., Parkinson Helen, Piccolo Stefano, Pinheiro Inês, Pombo Ana, Popp Christian, Reik Wolf, Roman-Roman Sergio, Rosenstiel Philip, Schultze Joachim L., Stegle Oliver, Tanay Amos, Testa Giuseppe, Thanos Dimitris, Theis Fabian J., Torres-Padilla Maria Elena, van Oudenaarden Alexander, Bruining Hilgo, Jongsma Karin R., Pasterkamp R. Jeroen, van Oudenaarden Alexander, 2020, In: Nature. 587 , p. 377-386 10 p.

Thinking “ethical” when designing an international, cross-disciplinary biomedical research consortium

Torres-Padilla Maria Elena, Bredenoord Annelien L., Jongsma Karin R., Lunkes Astrid, Marelli Luca, Pinheiro Ines, Testa Giuseppe 2020, In: EMBO Journal. 39 , p. 1-5

What constitutes a reasonable compensation for non-commercial oocyte donors:an analogy with living organ donation and medical research participation

Kool Emy, van der Graaf Rieke, Bos Annelies, Fauser Bartholomeus, Bredenoord Annelien 1 nov 2019, In: Journal of Medical Ethics. 45 , p. 736-741 6 p.

All research output

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